The question to what extent the molecular weight (MW) of the respective Chelatsubstanz (EDTA, DMSA, DMPS, etc) on the binding capacity and decide whether a comparison of the molecular weight is necessary to the effectiveness of a Chelatsubstanz confirm we received in various ways.
The response from Heinz Scholz, medicinal chemists and Journalist:
EDTA anion:
has 2 lone pairs of the nitrogen atom and 4 carboxyl groups. These represent a complex compound. EDTA can thus bind to 6-fold to a cation. MW = 292.2
DMSA: MW = 188.2; has two SH-groups
DMPS: MW = 188.3; 2 has SH groups
It would be a fallacy to assume that EDTA is more effective because of the higher Chelatsubstanz MG.
a) In toxicology, there is no all-embracing Chelatsubstanz that is in any case, the drug of choice.
b) The EDTAs as well as the oxygen affinity are DTPAs Chelatstubstanzen, DMSA and DMPS are sulfuraffin. It is this affinity, which determines the Bindefreudigkeit with the different metals. The molecular weight is irrelevant. This affinity determined, why is such as mercury bound well by DMPS and DMSA and EDTA and DTPA little.
c) The amount administered plays a crucial role. For example, given with 2gr EDTA, for 2 hours (= 1g / h) achieved less than 3gr EDTA in 3 hours. Or do we compare with oral DMSA 100 mg to 1000 mg. The higher dose achieved Viewed Math, a 10-fold binding and excretion. The urine is, provided it is applied the chelatsubstanzgerechte protocol, a significantly higher metal concentrations. Similarly, a 5 ml vial contains 250 mg DMPS DMPS. One capsule of DMPS (Dimaval) contains 100mg. Thus, the injection will achieve a higher metal binding, the metal concentration in urine will be higher.
d) The nature of the administration decides on metal binding and excretion. Thus, a direct comparison of DMPS DMPS IV capsule is hardly possible. The solution for injection in the bloodstream is rapidly active, while the capsule is dissolved only in the digestive tract must. There, the oral DMPS or DMSA is first active, ie, first the bound metals found there. A selective intestinal decontamination before use of oral chelation therapy will optimize the treatment outcome significantly.
During our workshops, these and other topics on the mechanisms of the various Chelatsubstanzen be answered. Particulars under www.microtrace.de
